Carbonate Ion → Tert-butyl 4-fluoro-4-((2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yloxy)methyl)piperidine-1-carboxylate

HRID 2160740Notes

Reaction equation

HRID 2160740 reaction equation
[C:26](=[O:27])([O-:28])[O-:29].[CH3:1][O:2][CH2:3][CH2:4][O:5][c:6]1[cH:7][c:8]2[n:9]([cH:10][cH:11]1)[c:12](-[c:15]1[n:16][c:17]3[c:18]([OH:25])[cH:19][cH:20][cH:21][c:22]3[cH:23][cH:24]1)[cH:13][n:14]2.[Cs+:30].[Cs+:31].[F:32][C:33]1([CH2:46][O:47][S:48]([CH3:49])(=[O:50])=[O:51])[CH2:34][CH2:35][N:36]([C:39](=[O:40])[O:41][C:42]([CH3:43])([CH3:44])[CH3:45])[CH2:37][CH2:38]1>>[CH3:1][O:2][CH2:3][CH2:4][O:5][c:6]1[cH:7][c:8]2[n:9]([cH:10][cH:11]1)[c:12](-[c:15]1[n:16][c:17]3[c:18]([O:25][CH2:46][C:33]4([F:32])[CH2:34][CH2:35][N:36]([C:39](=[O:40])[O:41][C:42]([CH3:43])([CH3:44])[CH3:45])[CH2:37][CH2:38]4)[cH:19][cH:20][cH:21][c:22]3[cH:23][cH:24]1)[cH:13][n:14]2

Participants

5

Reactant 4

HCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 222484024-Fluoro-4-(methylsulfonyloxymethyl)-1-piperidinecarboxylic acid tert-butyl esterHCID 66781369HCID 66781369, compound

Product 1

HCID 66782159Tert-butyl 4-fluoro-4-((2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yloxy)methyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-1e7a05e8f5a84ac99b5bcaa862d92581
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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