Methanol → 1-(tert-butoxycarbonyl)-4-((1-trityl-1H-imidazol-4-yl)methyl)piperidine-4-carboxylic acid

Participants

Reaction Steps

To a solution of 1-tert-butyl 4-ethyl 4-((1-trityl-1H-imidazol-4-yl)methyl)piperidine-1,4-dicarboxylate from step A (330 mg, 0.57 mmol) in 1:1:2 THF:MeOH:H2O (10 mL) was added LiOH (136 mg, 5.7 mmol). The mixture was refluxed until LCMS showed complete conversion to product, then concentrated under vacuum, dissolved in water (3 mL), neutralized to pH 5-6 with aq. NaHSO4, and extracted with ethyl acetate (3×10 mL). The combined organic phases were washed with brine, dried over Na2SO4, and concentrated under vacuum to give the title compound (273 mg, 86%). MS (ES+) [M+H]+=552.2.

Provenance & Evidence