1,2-Dichloroethane → HCID 19932173, compound

Participants

Reaction Conditions

Reaction Steps

200 mg of 3-chloroperoxybenzoic acid were added to a solution of 150 mg of 4-cyano-1-(diethylcarbamoyl)-3-(2-ethyl-6-methylphenylthio)pyrazole [prepared as described in step (3) above] in 5 ml of 1,2-dichloroethane, and the resulting mixture was heated at 50° C. for 2 hours. At the end of this time, the reaction mixture was poured into an aqueous solution of sodium sulfite and extracted with methylene chloride. The extract was washed with an aqueous solution of sodium hydrogencarbonate, dried over anhydrous sodium sulfate and concentrated by evaporation under reduced pressure. The concentrate was purified by column chromatography through silica gel, eluted with a 6:1 by volume mixture of hexane and ethyl acetate, to afford 153 mg (yield 95%) of the title compound, melting at 101°-102° C.

Provenance & Evidence