1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid → 7-(1-tert-Butoxycarbonylamino-6-azaspiro[2.5]oct-6-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid

HRID 2161106Notes

Reaction equation

HRID 2161106 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH:9]1[CH2:10][C:11]12[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]2.[CH:17]1([n:20]2[cH:21][c:22]([C:33](=[O:34])[OH:35])[c:23](=[O:32])[c:24]3[cH:25][c:26]([F:31])[c:27]([F:30])[cH:28][c:29]23)[CH2:18][CH2:19]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][CH:9]1[CH2:10][C:11]12[CH2:12][CH2:13][N:14]([c:27]1[c:26]([F:31])[cH:25][c:24]3[c:23](=[O:32])[c:22]([C:33](=[O:34])[OH:35])[cH:21][n:20]([CH:17]4[CH2:18][CH2:19]4)[c:29]3[cH:28]1)[CH2:15][CH2:16]2

Participants

3

Reactant 2

HCID 52104221-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acidHCID 15282171tert-Butyl 6-azaspiro[2.5]octan-1-ylcarbamate

Product 1

HCID 675530147-(1-tert-Butoxycarbonylamino-6-azaspiro[2.5]oct-6-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid

Sources & evidence

ORD record
ord-f0ede047c6a64b30bb3ef348b7623ee2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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