Hydrochloric Acid → HCID 69069405, compound

Participants

Reaction Steps

A solution of 3-{6-[2-(2-chloro-6-fluoro-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-benzoic acid [0.1 g, Example 20(b)] in DCM and MeOH is treated with a saturated solution of hydrogen chloride in EtOAc (2 mL) and the mixture is concentrated, dissolved in acetonitrile and water, and lyophilized to afford 3-{6-[2-(2-chloro-6-fluoro-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-benzoic acid hydrochloride [83 mg, Example 15(c)] as a solid. LCMS: RT=2.85 minutes, MS: 402 (M+H).

Provenance & Evidence