HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 4-Chloro-6-(3,4-dimethoxy-phenyl)-2-methoxy-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 4-Chloro-6-(3,4-dimethoxy-phenyl)-2-methanesulfonyl-pyrimidine | HCID 57636140 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 4-Chloro-6-(3,4-dimethoxy-phenyl)-2-methoxy-pyrimidine | HCID 57636117 | 100% |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
A mixture of 4-chloro-6-(3,4-dimethoxy-phenyl)-2-methanesulfonyl-pyrimidine [5.05 g, 0.0154 mol, Intermediate (49)] in ethylene glycol dimethyl ether (100 mL) is chilled to 0° C. and added 25 wt % sodium methoxide in MeOH (1.32 mL, 0.0231 mol). After 15 minutes the reaction is allowed to warm to ambient temperature and stirred overnight. The mixture is concentrated to afford 4-chloro-6-(3,4-dimethoxy-phenyl)-2-methoxy-pyrimidine [4.3 g, 100%, Intermediate (50)]
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08193183B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-bd8e93ebba644cc69b4c2d20511e4ab0 |
| Source note | uspto-grants-2012_06 |