Hydrochloric Acid → HCID 69062600, compound

Participants

Reaction Steps

By proceeding in a similar manner to Example 43(b) but substituting 2-(4-amino-phenyl)-ethylamine for 2-(4-nitro-phenyl)-ethylamine, and substituting acetonitrile for EtOH as solvent in Step 3 there is prepared [2-(4-amino-phenyl)-ethyl]-[2-methoxy-6-(3-methoxy-phenyl)-pyrimidin-4-yl]-amine which is dissolved in ether and treated with 1 M hydrogen chloride in ether affording [2-(4-amino-phenyl)-ethyl]-[2-methoxy-6-(3-methoxy-phenyl)-pyrimidin-4-yl]-amine hydrochloride [52.4 mg, 68%, Example 43(j)] as a solid. LC/MS: RT=1.72 minutes, MS: 351 (M+H). 1H NMR [300 MHz, (CD3)2SO]: □7.24-7.5 (7H, m), 7.08 (1H, m), 6.65 (1H, s), 4 (3H, s), 3.8 (3H, s), 3.64 (2H, m), 2.92 (2H, m).

Provenance & Evidence