Hydrochloric Acid → HCID 69063745, compound

Participants

Reaction Steps

By proceeding in a similar manner to Example 43(b) but substituting 4-methoxy-benzylamine for 2-(4-nitro-phenyl)-ethylamine, and substituting acetonitrile for EtOH as solvent in Step 3 there is prepared (4-methoxy-benzyl)-[2-methoxy-6-(3-methoxy-phenyl)-pyrimidin-4-yl]-amine which is dissolved in ether and treated with 1 M hydrogen chloride in ether affording (4-methoxy-benzyl)-[2-methoxy-6-(3-methoxy-phenyl)-pyrimidin-4-yl]-amine hydrochloride [56.3 mg, 73%, Example 43(k)] as a solid. LC/MS: RT=2.5 minutes, MS: 352 (M+H). 1H NMR [300 MHz, (CD3)2SO]: □7.36-7.5 (3H, m), 7.28 (2H, d, J=9.2 Hz), 7.1 (1H, m), 6.9 (2H, d, J=9.2 Hz), 6.65 (1H, s), 4.57 (2H, d, J=5 Hz), 4 (3H, s), 3.8 (3H, s), 3.72 (3H, s). IC50=1073 nM

Provenance & Evidence