1-(3-Fluoro-4-(5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yloxy)phenyl)-3-(2-(4-fluorophenyl)acetyl)thiourea → 4-(6-(3-(Dimethylamino)propoxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yloxy)-3-fluorobenzenamine
Reaction equation
[F:1][c:2]1[c:3]([O:4][c:5]2[n:6][cH:7][n:8][n:9]3[c:10]2[c:11]([CH3:21])[c:12]([O:14][CH2:15][CH2:16][CH2:17][N:18]([CH3:19])[CH3:20])[cH:13]3)[cH:22][cH:23][c:24]([N+:26]([O-:27])=[O:28])[cH:25]1.[F:29][c:30]1[cH:31][c:32]([NH:33][C:34]([NH:35][C:36](=[O:37])[CH2:38][c:39]2[cH:40][cH:41][c:42]([F:43])[cH:44][cH:45]2)=[S:46])[cH:47][cH:48][c:49]1[O:50][c:51]1[c:52]2[c:53]([CH3:54])[cH:55][cH:56][n:57]2[n:58][cH:59][n:60]1>>[F:1][c:2]1[c:3]([O:4][c:5]2[n:6][cH:7][n:8][n:9]3[c:10]2[c:11]([CH3:21])[c:12]([O:14][CH2:15][CH2:16][CH2:17][N:18]([CH3:19])[CH3:20])[cH:13]3)[cH:22][cH:23][c:24]([NH2:26])[cH:25]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-72602055a985436a9a8debb22dc5981a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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