HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2,2-Difluoro-2-phenylacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ethyl 2,2-difluoro-2-phenylacetate | HCID 10631860 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2,2-Difluoro-2-phenylacetamide | HCID 269656 | — |
Reaction Steps
A solution of the above difluoro-phenyl-acetic acid ethyl ester and NH3 in MeOH (7 M, 10 mL) is heated to 60° C. for 2 h in a pressure tube. The mixture is cooled to room temperature, and concentrated to afford 2,2-difluoro-2-phenyl-acetamide (0.33 g). LCMS: RT=1.7 minutes; MS: 172 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08193183B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-ce37525d48ee4ae6af4aa96241137df7 |
| Source note | uspto-grants-2012_06 |