Neopentyl glycol → 5-(5,5-Dimethyl-[1,3,2]dioxaborinan-2-yl)-thiophene-2-carboxylic acid

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Reaction Steps

5-(Dihydroxyboryl)-2-thiophenecarboxylic acid (527 mg, 3.1 mmol) and 2,2-dimethyl-propane-1,3-diol (361 mg, 3.4 mmol) are stirred in THF (10 mL) for 19 hours and concentrated in vacuo to afford 5-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)-thiophene-2-carboxylic acid (748 mg) as a solid. LCMS: RT=1.15 minutes; 1H NMR [300 MHz, (CD3)2SO]: □13.15 (1H, s); 7.7 (1H, m); 7.45 (1H, m); 3.75 (4H, s); 0.95 (6H, s).

Provenance & Evidence