Dichloromethane → 4-(4'-Difluoromethoxy-biphenyl-4-yloxymethyl)-5-methyl-furan-2-carboxylic acid methyl ester

HRID 2162734Notes

Reaction equation

HRID 2162734 reaction equation
[C:39](=[O:40])([O-:41])[O-:42].[CH3:1][O:2][C:3](=[O:4])[c:5]1[o:6][c:7]([CH3:27])[c:8]([CH2:10][O:11][c:12]2[cH:13][cH:14][c:15]([B:18]3[O:19][C:20]([CH3:21])([CH3:22])[C:23]([CH3:24])([CH3:25])[O:26]3)[cH:16][cH:17]2)[cH:9]1.[Cl:45][CH2:46][Cl:47].[Cs+:43].[Cs+:44].[F:28][CH:29]([O:30][c:31]1[cH:32][cH:33][c:34]([I:37])[cH:35][cH:36]1)[F:38].[O:48]1[CH2:49][CH2:50][O:51][CH2:52][CH2:53]1>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[o:6][c:7]([CH3:27])[c:8]([CH2:10][O:11][c:12]2[cH:13][cH:14][c:15](-[c:34]3[cH:33][cH:32][c:31]([O:30][CH:29]([F:28])[F:38])[cH:36][cH:35]3)[cH:16][cH:17]2)[cH:9]1

Participants

7

Reactant 6

HCID 6344DichloromethaneHCID 19660Carbonate IonHCID 312751,4-DioxaneHCID 104967Cesium cation2×HCID 27370081-(Difluoromethoxy)-4-iodobenzeneHCID 588241625-Methyl-4-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxymethyl]-furan-2-carboxylic acid methyl ester

Product 1

HCID 588241674-(4'-Difluoromethoxy-biphenyl-4-yloxymethyl)-5-methyl-furan-2-carboxylic acid methyl ester

Sources & evidence

ORD record
ord-020a45d908c8433c90df3e19c1241e43
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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