反应详情

温度

60 °C

To a solution of chlorosulfonic acid (12.0 mL, 180 mmol) at 0° C. was added 2-nitrophenol (8.35 g, 60.0 mmol) in small portions over 1 h. The reaction was heated to 60° C. for 20 minutes and allowed to stir for 18 h at 25° C. The reaction was quenched by pouring it into 100 g of ice. The reaction was extracted with chloroform (3×), washed with cold water (2×), dried over MgSO4, filtered, and concentrated to give 9.06 g (64%) of the title compound.

1. customThe reaction was quenched
2. additionby pouring it into 100 g of ice
3. extractionThe reaction was extracted with chloroform (3×)
4. washwashed with cold water (2×)
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. concentrationconcentrated