反应详情

Nitrosonium tetrafluoroborate 45 g (0.38 mol) was added in three portions to a 0° C. solution of 4,4-dimethyl-1-hexene (43 g, 0.38 mol) in acetonitrile (100 mL). After stirring at ambient temperature for 1 h, the reaction mixture was filtered and the filtrate was concentrated in vacuo. The residue was dissolved in ethyl acetate and washed with water, saturated aqueous sodium bicarbonate and brine, dried (magnesium sulfate), filtered and concentrated in vacuo to afford 4-(2,2-dimethylbutyl)-2-methyl-1H-imidazol-1-ol which was used in the subsequent step without further purification.

1. filtrationthe reaction mixture was filtered
2. concentrationthe filtrate was concentrated in vacuo
3. dissolutionThe residue was dissolved in ethyl acetate
4. washwashed with water, saturated aqueous sodium bicarbonate and brine
5. dry with materialdried (magnesium sulfate)
6. filtrationfiltered
7. concentrationconcentrated in vacuo