Water → HCID 70609230, compound

Participants

Reaction Steps

cis-1-Cyclopropylcarbonyl-4-phenyl-3-piperidinol (10.01 g, 41.1 mmoles, described above) is suspended in dry tetrahydrofuran (250 ml) and added dropwise to a suspension of lithium aluminum hydride (5.0 g, 94.7 mmoles) in tetrahydrofuran. The mixture is stirred at room temperature for 2 hours. Water (60 ml) is added slowly to the cooled reaction mixture, followed by aqueous sodium hydroxide (60 ml, 3N). The gelatinous precipitate is removed by filtration and the filtrate evaporated. The solid residue is dissolved in methylene chloride, washed with brine, dried (MgSO4) and evaporated. The residue is crystallized from hexane to give the title compound, mp 98°-100° C.

Provenance & Evidence