Hydrochloric Acid → 80067-61-4

Participants

Reaction Steps

A solution of trans-1-phenylmethyl-4-phenyl-3-piperidinol (11.00 g, 51.5 mmoles, described in Example 11) in anhydrous ethanol (150 ml) containing concentrated hydrochloric acid (5 ml) is hydrogenated over 10% palladium on charcoal under 50 p.s.i. at 50° C. for 8 hours. The catalyst is removed by filtration over diatomaceous earth and the filtrate is evaporated. The residue is triturated with isopropanol and crystallized from methanol-ether to give the title compound, isolated as the hydrochloride salt, mp 233°-235° C.

Provenance & Evidence