6-Trifluoromethyl-indan-1-ylamine hydrochloride → 6-(Trifluoromethyl)-2,3-dihydro-1H-inden-1-amine

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Reaction Steps

The hydrochloride salt of 6-trifluoromethyl-1-aminoindane was prepared by dissolving the amine base in ether and saturating the etheral solution with gaseous HCl. The hydrochloride salt precipitated and was separated by filtration. 300 mg. of a colorless solid were obtained melting with partial decomposition at about 250° C. and showing a single spot on TLC were obtained. 6-Trifluoromethyl-1-aminoindane hydrochloride thus prepared melted above 260° C. after recrystallization from a methanol-ethyl acetate solvent mixture; pKa = 8.52.

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