Trifluoroacetic acid → HCID 131711394, compound

Participants

Reaction Steps

A solution of XX (1.1 g, 1.50 mmol) in 9 ml of 30% trifluoroacetic acid in methylene chloride was allowed to stand for 30 min. at room temperature. The reaction mixture was treated in the same manner as described for the preparation of XI in part (j). The resulting solid was recrystallized from chloroform-petroleum ether; yield 0.923 g (90%), m.p. 130-133° C., Rf1 0.06, Rf2 0.12, Rf3 0.21. Calcd. for C27H35N6O12F3.1/2H2O: C, 46.22; H, 5.17; N, 11.98%. Found: C, 46.06; H, 5.16; N, 11.82%. Amino acid analysis: Glu, 0.98; Pro, 0.90; Gly, 2.10; Val, 1.00.

Provenance & Evidence