反应详情

Compound 8 -- A mixture of 4-(2-chloroacetamido)-N-(2-hydroxyethyl)benzamide (39.3 g., 0.153 mole) and potassium thiolacetate (18.3 g., 0.16 mole) in 650 ml. of acetone is heated at reflux temperature for a period of 2 hr. After standing overnight, the reaction mixture is filtered, the filtercake washed with acetone, slurried with water, filtered and the filtercake washed with water and dried to afford 34.7 g. of crude product. Crystallization of this material from ethyl acetate-methanol affords analytically pure 4-[2-(ACETYLTHIO)ACETAMIDO]-N-(2-HYDROXYETHYL)BENZAMIDE, m.p. 190.0°-192.0° C. (corr.) in 57% yield.

1. temperatureat reflux temperature for a period of 2 hr
2. filtrationthe reaction mixture is filtered
3. washthe filtercake washed with acetone
4. filtrationfiltered
5. washthe filtercake washed with water
6. customdried
7. customto afford 34.7 g
8. customCrystallization of this material from ethyl acetate-methanol