HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Pyrrolidone → 10-(1-Pyrrolin-2-YL)-2-(trifluoromethyl)phenoxazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Pyrrolidone | HCID 12025 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 2-Trifluoromethylphenoxazine | HCID 10467321 | — |
| Product | 10-(1-Pyrrolin-2-YL)-2-(trifluoromethyl)phenoxazine | HCID 22754280 | — |
Reaction Steps
Reaction of 2-(trifluoromethyl)phenoxazine, 2-pyrrolidinone and phosphorus oxychloride according to the procedure of Example 1 provides the free base 10-(1-PYRROLIN-2-YL)-2-(TRIFLUOROMETHYL)PHENOXAZINE as a distallable oil, b.p. 140-146° C. at 0.1 mm Hg. Conversion of the free base to the hydrochloride salt affords 10-(1-PYRROLIN-2-YL)-2-(TRIFLUOROMETHYL)PHENOXAZINE HYDROCHLORIDE, m.p. 219.5-222.5° C. (dec.) (corr.), in a 62% overall yield by triturating with warm benzene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04132794 |
| Source dataset | uspto-grants-1979_01 |
| ORD ID | ord-1e6d7f75bae94c7fb0567e6267de4ed1 |
| Source note | uspto-grants-1979_01 |