HuagongsheHuagongshe Chemistry Print Report · For research reference only
9,9-Dimethyl-9,10-dihydroacridine → 9,9-Dimethyl-10-(5-methyl-1-pyrrolin-2-YL)acridan
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 9,9-Dimethyl-9,10-dihydroacridine | HCID 22647 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 5-Methyl-2-pyrrolidone | HCID 66055 | — |
| Product | 9,9-Dimethyl-10-(5-methyl-1-pyrrolin-2-YL)acridan | HCID 3044167 | 11% |
Reaction Steps
Reaction of 9,9-dimethylacridan, 5-methyl-2-pyrrolidinone and phosphorus oxychloride according to the procedure of Example 1 provides the free base 9,9-DIMETHYL-10-(5-METHYL-1-PYRROLIN-2-YL)ACRIDAN as a distillable oil, b.p. 160-180° C. at 0.15 mm Hg. in 11% yield. Conversion of the free base to the hydrochloride salt affords 9,9-DIMETHYL-10-(5-METHYL-1-PYRROLIN-2-YL)ACRIDAN HYDROCHLORIDE, m.p. 232.5-234.5° C. (dec.) (corr.), by trituration with hot benzene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04132794 |
| Source dataset | uspto-grants-1979_01 |
| ORD ID | ord-30e420669ce646099f91383062b5a813 |
| Source note | uspto-grants-1979_01 |