Dichloromethane → HCID 70606043, compound

Participants

Reaction Steps

To a solution of 391 mg. of mercuric acetate in 15 ml. of dichloromethane containing 15 ml. of acetic acid was added in one portion 435 mg. of 1-(1-tert.-butyloxycarbonyl-2-hydroxy-3-bromo-1-propenyl)-3-phenoxyacetamido-4-formylthio-azetidin-2-one. The reaction mixture was stirred at room temperature for 5 minutes, and then hydrogen sulfide gas was bubbled into the reaction mixture for 1 minute. The reaction mixture was filtered through a filter aid and charcoal. The filtrate was evaporated to dryness under reduced pressure to provide tert.-butyl 7-phenoxyacetamido-3-hydroxy-3-cephem-4-carboxylate.

Provenance & Evidence