反应详情

To 3.03 g of 7-chloro-5-phenyl-1H-1,5-benzodiazepin-4-one-2-thione in a solution of 0.40 g sodium hydroxide and 15 ml of methanol is added, with stirring a solution of 1.39 g of methyl iodide in 5 ml of methanol. Stirring is continued for 1 hour, the reaction is evaporated, diluted with 30 ml methylene chloride and filtered through a short Florisil column. After washing the column with ethyl acetate, the combined filtrates are evaporated to give the title compound.

1. customthe reaction is evaporated
2. additiondiluted with 30 ml methylene chloride
3. filtrationfiltered through a short Florisil column
4. washAfter washing the column with ethyl acetate
5. customthe combined filtrates are evaporated