Diazomethane → 2-Methoxy-7-chloro-5-phenyl-3H-1,5-benzodiazepin-4-one

Participants

Reaction Steps

To 11.4 g of 7-chloro-5-phenyl-1H-1,5-benzodiazepine-2,4-dione stirred in 150 ml methanol is added, dropwise, approximately 2.1 g of diazomethane in ether. After addition is complete, the reaction is stirred for 1 hour and filtered. The filtrate is evaporated and the residue diluted with a small amount of ether. The suspension is filtered and the filtrate evaporated to give the title compound.

Provenance & Evidence