Acetic Acid → HCID 20329336, compound

HRID 2163294Notes

Reaction equation

HRID 2163294 reaction equation
C([O:4][CH:5]1[C:11](=[O:12])[N:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:9]2[CH:19]=[C:20]([Cl:23])[CH:21]=[CH:22][C:8]=2[N:7]2[CH:24]=[N:25][N:26]=[C:6]12)(=O)C.[OH-].[Na+].C(O)(=O)C>C(O)C>[OH:4][CH:5]1[C:11](=[O:12])[N:10]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:9]2[CH:19]=[C:20]([Cl:23])[CH:21]=[CH:22][C:8]=2[N:7]2[CH:24]=[N:25][N:26]=[C:6]12

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 14798Sodium HydroxideHCID 20395211HCID 20395211, compound

Product 1

HCID 20329336HCID 20329336, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3.5 g of 4-acetoxy-8-chloro-6-phenyl-4H-s-triazolo[4,3-a][1,5]benzodiazepin-5-one and 2.8 ml of 4N aqueous sodium hydroxide in 160 ml of ethanol are stirred overnight at 25°. The reaction is neutralized with 0.5 g of acetic acid and the solvent is evaporated. The residue is partitioned between chloroform and water, the organic phase is dried and the solvent evaporated to give the title compound.

Workup

  1. customthe solvent is evaporated
  2. customThe residue is partitioned between chloroform and water
  3. customthe organic phase is dried
  4. customthe solvent evaporated

Sources & evidence

ORD record
ord-7a95e50296c649f39a741c80ff392246
Source dataset
uspto-grants-1979_01
Patent number
US04133809

Reaction notes

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