6-Methoxy-2-(4-methoxyphenyl)benzo[b]thiophene → 2-(4-Hydroxyphenyl)benzo(b)thiophen-6-ol

Participants

Reaction Conditions

Reaction Steps

A mixture of 16.5 grams of 2-(4-methoxyphenyl)-6-methoxybenzothiophene and 50 grams of pyridine hydrochloride was prepared. The mixture was heated at 220° C. for six hours. The resulting mixture then was poured into an ice-water mixture. The mixture was filtered, and the collected solid was dried in air and recrystallized from methanol to obtain 10.5 grams of 2-(4-hydroxyphenyl)-6-hydroxybenzothiophene, melting point 305°-306° C.

Provenance & Evidence