Sulfuric Acid → alpha-(1-Isopropyl-3-azetidinyl)-alpha-phenyl-alpha-(2-pyridyl)acetamide

Participants

Reaction Conditions

Reaction Steps

To 80 ml. of concentrated sulfuric acid preheated to 70° C. was added 15 g. (0.052 mole) of α-(1-isopropyl-3-azetidinyl)-α-phenyl-α-(2-pyridyl)acetonitrile at a rate to maintain 65°-70° C. The solution was heated to 70° C. for 18 hrs. and poured on ice. The mixture was made basic with 50% sodium hydroxide (with ice cooling and extracted with chloroform. The chloroform was dried (sodium sulfate) and concentrated. The residue was crystallized twice from ethyl acetate-isopropyl ether. Yield 6 g. (37%), m.p. 140°-141° C.

Provenance & Evidence