Potassium Hydroxide → HCID 12822283, compound

HRID 2163346Notes

Reaction equation

HRID 2163346 reaction equation
[C:1]1([C:7]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)([CH:10]2[CH2:13][N:12]([CH:14](C3C=CC=CC=3)C)[CH2:11]2)[C:8]#[N:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+]>[Pd].C(O)C>[C:1]1([C:7]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)([CH:10]2[CH2:13][N:12]([CH3:14])[CH2:11]2)[C:8]#[N:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 12822285HCID 12822285, compound

Product 1

HCID 12822283HCID 12822283, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 800 ml. of ethanol and 59 g. (0.13 mole) of α,α-diphenyl-α-[1-(1-phenylethyl)-3-azetidinyl]acetonitrile methobromide was treated with 7.12 g. (0.13 mole) of potassium hydroxide and 0.25 g. of 10% palladium on carbon. The mixture was shaken under initial hydrogen pressure of 45 p.s.i. at ambient temperature for 24 hours. The mixture was filtered and the filtrate concentrated. The residue was crystallized from isooctane to give 21.7 g. (64%) of product melting 112°-115° C.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate concentrated
  3. customThe residue was crystallized from isooctane
  4. customto give 21.7 g
  5. custommelting 112°-115° C.

Sources & evidence

ORD record
ord-85655ade377442d4acc403c973224fb8
Source dataset
uspto-grants-1979_01
Patent number
US04133881

Reaction notes

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