HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 4-(1-Naphthyl)-2,2-dimethyl-7-(3-methylamino-2-hydroxy-propoxy)-2H chromene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 2,2-Dimethyl-4-(naphthalen-1-yl)-7-[(oxiran-2-yl)methoxy]-2H-1-benzopyran | HCID 23330742 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(1-Naphthyl)-2,2-dimethyl-7-(3-methylamino-2-hydroxy-propoxy)-2H chromene | HCID 54425743 | 63% |
Reaction Steps
Methylamine (9.5 ml) was added to 7-(2,3-epoxypropoxy)-2,2-dimethyl-4-(1-naphthyl)-2H chromene (4.5g., 0.013 moles) in ethanol (9.5ml) and the solution left to stand at room temperature for 48 hours. Removal of solvent gave the title compound as an orange oil (3.2g., 63%). N.M.R. (τCDCl3) 8.54(s, 3H, CH3 -), 8.48(s, 3H, CH3 -), 7.06(s, 3H, N-CH3), 6.72(d, 2H, -CHCH2 -), 6.05(d, 2H, -CH2CH-), 4.51(s, 1H, vinylic CH), 3.40-3.80 (m, 3H, aromatic H'5), 2.10-2.75(m, 7H, aromatic H's).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04133883 |
| Source dataset | uspto-grants-1979_01 |
| ORD ID | ord-876a02b3e0024f9dbf12552e6fc1d505 |
| Source note | uspto-grants-1979_01 |