Ethanol → Morpholine, acetate

Into a suspension of 1.0 g (0.00186 mole) of 4-[NG -nitro-N2 -(6,7-dimethoxy-2-naphthalenesulfonyl)-L-arginyl] morpholine and 0.1 g of palladium black in 30 ml of ethanol and 10 ml of acetic acid was passed hydrogen gas for 60 hours at room temperature. Upon completion of the reaction, the catalyst was filtered off, and the solvent was evaporated under reduced pressure to give a viscous oily residue, which was taken up in methanol and reprecipitated with ether to afford 4-[N2 -(6,7-dimethoxy-2-naphthalenesulfonyl)-L-arginyl] morpholine acetate in the powder form in a yield of 82%.

1. customfor 60 hours
2. customat room temperature
3. customUpon completion of the reaction
4. filtrationthe catalyst was filtered off
5. customthe solvent was evaporated under reduced pressure
6. customto give a viscous oily residue, which
7. customreprecipitated with ether

ORD record

ord-453c531561be443a88c92d31fcffcb9b

Source dataset

uspto-grants-1979_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04133880