HCID 86735750, compound → 9-Fluoro-11beta-hydroxy-17-(phenylthio)androsta-1,4,16-trien-3-one

Participants

Reaction Conditions

Reaction Steps

A suspension of 6.0 g of 9-fluoro-11β-hydroxy-17,17-bis(phenylthio)androsta-1,4-dien-3-one in 120 ml of diethylbenzene is stirred at 190° C. for 45 minutes. The solution is cooled at 0° C. and a solid crystallizes. This is filtered and dried in vacuo to give 5.5 g of material. Recrystallization from chloroform-methanol gives 4.21 g of the title compound, melting point 253°-255° C. (dec.).

Provenance & Evidence