Pyridine → 4-Acetamido-2-bromo-thiazole

Participants

Reaction Conditions

Reaction Steps

4-Amino-2-bromothiazole hydrobromide (52 g, 0.2 m) was suspended in acetic anhydride (200 ml.) then treated dropwise with pyridine (100 ml.), maintaining the temperature at 0° C. by means of an ice bath. After the addition was complete, the reaction mixture was stirred for 2 hours at room temperature then poured onto 20% aqueous sodium acetate (2 1.) The solution was cooled, filtered and the precipitate washed with water (2 × 200 ml.). The product was air dried and recrystallised from acetone to give 4-acetamido-2-bromo-thiazole (35 g, 80%). m.p. 165° C.

Provenance & Evidence