Sodium Acetate → 4-Propionamidothiazole

HRID 2163515노트

반응식

HRID 2163515 반응식
Br[C:2]1[S:3][CH:4]=[C:5]([NH:7][C:8](=[O:11])[CH2:9][CH3:10])[N:6]=1.C([O-])(=O)C.[Na+].[H][H]>CO.[Pd]>[C:8]([NH:7][C:5]1[N:6]=[CH:2][S:3][CH:4]=1)(=[O:11])[CH2:9][CH3:10]

참가 물질

6

반응물 3

HCID 517045Sodium AcetateHCID 202940462-Bromo-4-propionamidothiazoleHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 202940354-Propionamidothiazole수율 17.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of 2-bromo-4-propionamidothiazole (4g) and sodium acetate (1.4g) in methanol (100 ml.) was hydrogenated at atmospheric pressure over 10% Pd/C catalyst (1.0g) until the theoretical uptake of hydrogen had occurred. The catalyst was removed by filtration and washed with methanol and the extracts evaporated in vacuo. The residue was recrystallised twice from carbon tetrachloride to give the title compound (1.9g) m.p. 129°-32° C. (Found: C, 46.3; H, 5.2; N, 17.7. C6H8N2OS requires C, 46.1; H, 5.2; N, 17.9%).

후처리

  1. customThe catalyst was removed by filtration
  2. washwashed with methanol
  3. customthe extracts evaporated in vacuo
  4. customThe residue was recrystallised twice from carbon tetrachloride

출처 및 근거

ORD 기록
ord-7122b2a4d2604830847ea4ab8f866639
출처 데이터셋
uspto-grants-1979_01
특허 번호
US04134984

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