Sodium Acetate → HCID 19385671, compound

Participants

Reaction Steps

A solution of 2-bromo-4-butyramidothiazole (4g) and sodium acetate (1.35g) in methanol (100ml) was hydrogenated at atmospheric pressure over 10% Pd/C (1g) as catalyst until theoretical uptake of hydrogen had occurred. The catalyst was removed by filtration and washed with methanol and the extracts evaporated in vacuo. The residue was recrystallised from hexane and the crystals sublimed at 50° C. at 0.2mm and the sublimate recrystallised from carbon tetrachloride to give the title compound (1.1g) m.p. 63°-6° C. (Found: C, 49.0; H, 5.9; N, 16.5. C7H10N2OS requires C, 49.4; H, 5.9; N, 16.5%).

Provenance & Evidence