N-Methylhomoveratrylamine → 1-[6,7-Dimethoxy-1(2H)-phthalazinone-2-yl]-3-[N-methyl-N-(2-(3,4-dimethoxy-phenyl)-ethyl)-amino]-propane hydrochloride

HRID 2163530Notes

Reaction equation

HRID 2163530 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[C:9](=[O:15])[N:8]([CH2:16][CH2:17][CH2:18][Cl:19])[N:7]=[CH:6]2.[CH3:20][O:21][C:22]1[CH:23]=[C:24]([CH2:30][CH2:31][NH:32][CH3:33])[CH:25]=[CH:26][C:27]=1[O:28][CH3:29]>ClC1C=CC=CC=1>[ClH:19].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[C:9](=[O:15])[N:8]([CH2:16][CH2:17][CH2:18][N:32]([CH3:33])[CH2:31][CH2:30][C:24]1[CH:25]=[CH:26][C:27]([O:28][CH3:29])=[C:22]([O:21][CH3:20])[CH:23]=1)[N:7]=[CH:6]2

Participants

4

Reactant 2

HCID 77039N-MethylhomoveratrylamineHCID 221501712-(3-chloropropyl)-6,7-dimethoxy-1(2H)-phthalazinone

Product 1

HCID 227528001-[6,7-Dimethoxy-1(2H)-phthalazinone-2-yl]-3-[N-methyl-N-(2-(3,4-dimethoxy-phenyl)-ethyl)-amino]-propane hydrochloride

Reagents, catalysts & solvents 1

HCID 7964ChlorobenzeneSolvent

Procedure

1-[6,7-Dimethoxy-1(2H)-phthalazinone-2-yl]-3-[N-methyl-N-(2-(3,4-dimethoxy-phenyl)-ethyl)-amino]-propane hydrochloride was prepared analogous to Example 1 (b) by reaction of 1-[6,7-dimethoxy-1(2H)-phthalazinone-2-yl]-3-chloro-propane with N-(3,4-dimethoxy-phenylethyl)-N-methylamine in chlorobenzene. M.p.: 200° C.

Sources & evidence

ORD record
ord-a3d06b36ae474ab49bcb1f5e2263c4a7
Source dataset
uspto-grants-1979_01
Patent number
US04134980

Reaction notes

Loading…