Benzyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-amine → 1-(6,7-Dimethoxy-4(3H)-quinazolinone-3-yl)-3-[N-benzyl-N-(2-(3,4-dimethoxy-phenyl)-ethyl)-amino]-propane

HRID 2163537Notes

Reaction equation

HRID 2163537 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]([CH2:15][CH2:16][CH2:17]Cl)[C:6]2=[O:19].[CH3:20][O:21][C:22]1[CH:23]=[C:24]([CH2:30][CH2:31][NH:32][CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH:25]=[CH:26][C:27]=1[O:28][CH3:29].C(Cl)(Cl)Cl.CO>ClC1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][N:7]([CH2:15][CH2:16][CH2:17][N:32]([CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[CH2:31][CH2:30][C:24]1[CH:25]=[CH:26][C:27]([O:28][CH3:29])=[C:22]([O:21][CH3:20])[CH:23]=1)[C:6]2=[O:19]

Participants

5

Reactant 3

HCID 200274Benzyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-amineHCID 21584188Chloroform methanolHCID 223266313-(3-chloropropyl)-6,7-dimethoxy-4(3H)-quinazolinone

Product 1

HCID 227528031-(6,7-Dimethoxy-4(3H)-quinazolinone-3-yl)-3-[N-benzyl-N-(2-(3,4-dimethoxy-phenyl)-ethyl)-amino]-propane

Reagents, catalysts & solvents 1

HCID 7964ChlorobenzeneSolvent

Procedure

1-(6,7-Dimethoxy-4(3H)-quinazolinone-3-yl)-3-[N-benzyl-N-(2-(3,4-dimethoxy-phenyl)-ethyl)-amino]-propane was prepared analogous to Example 1 (a) by reaction of 1-(6,7-dimethoxy-4(3H)-quinazolinone-3-yl)-3-chloro-propane with N-(3,4-dimethoxy-phenylethyl)-N-benzyl amine in chlorobenzene. Rf -value (chloroform/methanol = 9.1) : 0.75.

Sources & evidence

ORD record
ord-69c8e44c624b45d3863e3880fe5ed016
Source dataset
uspto-grants-1979_01
Patent number
US04134980

Reaction notes

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