HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform methanol → 1-(6,7-Dimethoxy-4(3H)-quinazolinone-3-yl)-3-[N-(2-(3,4-dimethoxy-phenyl)-ethyl)-amino]-propane-hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform methanol | HCID 21584188 | — |
| Reactant | 1-(6,7-Dimethoxy-4(3H)-quinazolinone-3-yl)-3-[N-benzyl-N-(2-(3,4-dimethoxy-phenyl)-ethyl)-amino]-propane | HCID 22752803 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 1-(6,7-Dimethoxy-4(3H)-quinazolinone-3-yl)-3-[N-(2-(3,4-dimethoxy-phenyl)-ethyl)-amino]-propane-hydrochloride | HCID 22752807 | — |
Reaction Steps
1-(6,7-Dimethoxy-4(3H)-quinazolinone-3-yl)-3-[N-(2-(3,4-dimethoxy-phenyl)-ethyl)-amino]-propane-hydrochloride was prepared analogous to Example 6 (b) by debenzylation of 1-(6,7-dimethoxy-4-(3-H)-quinazolinone-3-yl)-3-[N-benzyl-(2-(3,4-dimethoxy-phenyl)-ethyl)-amino]-propane in the presence of palladium-on-charcoal (10%) with hydrogen. Rf -value (chloroform/methanol = 9.1) : 0.45. M.p.: 192 -194° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04134980 |
| Source dataset | uspto-grants-1979_01 |
| ORD ID | ord-7567ff417abe47019243ddff5f2c6468 |
| Source note | uspto-grants-1979_01 |