Sodium Hydroxide → HCID 21317467, compound

HRID 2163544Notes

Reaction equation

HRID 2163544 reaction equation
[SH:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Cl[CH2:10][CH2:11][CH2:12][CH2:13][C:14]([N:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1)=[O:15].[OH-].[Na+]>O>[OH:8][C:5]1[CH:6]=[CH:7][C:2]([S:1][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)=[O:15])=[CH:3][CH:4]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 2401474-MercaptophenolHCID 532162HCID 532162, compound

Product 1

HCID 21317467HCID 21317467, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of 47.9 g (0.250 mole) of p-mercaptophenol, 51.4 g (0.250 mole) of 4-(5-chlorovaleryl)morpholine, 52 ml of 5N sodium hydroxide and 600 ml of water was heated to boiling and then stirred at 50° C. for one hour; and, thereafter, stirred at room temperature for 15 hours. The white, crystalline intermediate precipitated during this period. The dried, crude intermediate was recrystallized from benzene to give the intermediate, 4-[5-(4-hydroxyphenylthio)valeryl]morpholine, as white crystals, mp 112°-113° C.

Workup

  1. temperaturewas heated
  2. stirringand, thereafter, stirred at room temperature for 15 hours
  3. customThe white, crystalline intermediate precipitated during this period
  4. customThe dried, crude intermediate was recrystallized from benzene

Sources & evidence

ORD record
ord-1508b42a266b4d1180634cadec411a61
Source dataset
uspto-grants-1979_01
Patent number
US04134996

Reaction notes

Loading…