1-Butanol → Butyl anthranilate

Participants

Reaction Steps

453 parts of anthranilic acid methyl ester, 444 parts of n-butanol and 11 parts of potassium carbonate are heated together, the methanol thus formed is distilled off over a column. After an intermediate fraction containing methanol and n-butanol, the excess quantity of n-butanol is distilled off, towards the end this latter operational step is carried out in vacuo. The reaction lasts for about nine hours. The residue is distilled in vacuo, there are obtained 556 parts of pure anthranilic acid n-butyl ester (boiling point 130°-140° C. under 7 mm Hg, nD25 1.544, purity according to gas chromatography 99-100%). Yield: 96% of the theory.

Provenance & Evidence