1-Butanol → HCID 22752968, compound

Participants

Reaction Conditions

Reaction Steps

210 parts of 5-nitroanthranilic acid ethyl ester, 210 parts of n-butanol and 10 parts of potassium carbonate are refluxed for half an hour. The thus formed ethanol is then distilled off over a column. Distillation is continued until the boiling point of n-butanol is reached. 450 parts of cyclohexane are then added, and after addition of 4 parts each of bleaching earth and active charcoal the hot mixture is filtered, followed by cooling to 0° C. The reaction lasts for about 4 hours. The precipitate is filtered off, washed with about 100 parts of cyclohexane and dried in vacuo at 60° C. There are obtained 222 parts of 5-nitroanthranilic acid-n-butyl ester, melting point 91°-93° C. The yield is approximately 93% of the theory.

Provenance & Evidence