化工社化工社 化学情報印刷レポート · 研究参考用
Flurbiprofen Methyl Ester → Flurbiprofen
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Flurbiprofen Methyl Ester | HCID 4127 | — |
| 反応物 | Thallium (III) acetate | HCID 21915946 | — |
| 溶媒 | Acetic Acid Hexane | HCID 22590778 | — |
| 生成物 | Flurbiprofen | HCID 3394 | — |
反応手順
Following the procedure of Example 2, the enol ether of the formula ##STR9## is reacted with thallium (III) acetate in an aqueous acetic acid/hexane mixture at 25° to 50° C. until methyl 2-(2-fluoro-4-biphenylyl)propionate is formed. This ester is isolated from the reaction mixture and hydrolyzed to 2-(2-fluoro-4-biphenylyl)propionic acid (generic name, flurbiprofen) by the described procedure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04135051 |
| 出典データセット | uspto-grants-1979_01 |
| ORD ID | ord-e044dcb41ca14cb189b5460bfe31d3cd |
| 出典メモ | uspto-grants-1979_01 |