反应详情

464 g 1-acetyl-2,2,6-trimethyl-4-cyclohexene (V, prepared according to K. S. Ayyar Chem. Comm. 1973, 161) (2.8 moles) in 800 ml of ethanol and 3 g 10% palladium on charcoal are hydrogenated in an autoclave under a pressure of 50 atm and at 50° C. After the uptake ceases, the reaction mixture is filtered and concentrated by distillation under reduced pressure. The product cis-1-acetyl-2,2,6-trimethylcyclohexane (VI, containing about 10% of the trans isomer) is collected at 83°-88° c./12 mm; yield 420 g (90%).

1. customare hydrogenated in an autoclave under a pressure of 50 atm and at 50° C
2. filtrationAfter the uptake ceases, the reaction mixture is filtered
3. concentrationconcentrated by distillation under reduced pressure
4. additionThe product cis-1-acetyl-2,2,6-trimethylcyclohexane (VI, containing about 10% of the trans isomer)
5. customis collected at 83°-88° c