Potassium Hydroxide → HCID 22750663, compound

HRID 2163631Notes

Reaction equation

HRID 2163631 reaction equation
[CH3:1][C:2]1[C:12]2[CH2:11][CH2:10][C:9]3[CH:13]=[CH:14][CH:15]=[CH:16][C:8]=3[C:7]([CH2:18][CH2:19][CH2:20][NH:21][C:22](OCCC)=O)([OH:17])[C:6]=2[CH:5]=[CH:4][CH:3]=1.[OH-].[K+]>C(O)CCC>[CH3:1][C:2]1[C:12]2[CH2:11][CH2:10][C:9]3[CH:13]=[CH:14][CH:15]=[CH:16][C:8]=3[C:7]([CH2:18][CH2:19][CH2:20][NH:21][CH3:22])([OH:17])[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 70603625HCID 70603625, compound

Product 1

HCID 22750663HCID 22750663, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

12.5 g. of 1-methyl-10,11-dihydro-5-(3-methylcarbethoxyaminopropyl)-5-hydroxy-5H-dibenzo[a,d]cycloheptene, 14 g. of potassium hydroxide and 120 ml. of n-butanol are boiled at reflux for 17 hours under nitrogen and with strong stirring. The butanol is removed by distillation under reduced pressure. The residue is taken up in ether and washed with water. 1-Methyl-10,11-dihydro-5-(3-methylaminopropyl)-5-hydroxy-5H-dibenzo[a,d] cycloheptene is obtained as a thick oil by evaporation of the ether.

Workup

  1. temperatureat reflux for 17 hours under nitrogen and with strong stirring
  2. customThe butanol is removed by distillation under reduced pressure
  3. washwashed with water

Sources & evidence

ORD record
ord-453db8ce9e694d29ba23e43c6d865539
Source dataset
uspto-grants-1979_01
Patent number
US04136116

Reaction notes

Loading…