Ethyl Thioglycolate → HCID 12414524, compound

Participants

Reaction Steps

A solution of 1-benzoyl-3-methoxycarbonyl-4-piperidone (12 g; 0.046 mole) in absolute ethanol (150 cc), cooled to -10° C, is saturated with dry hydrochloric gas. Ethyl mercapto-acetate (10.8 g; 0.092 mole) is added thereto and a slight stream of hydrochloric gas is further passed therethrough at -10° C during 5 hours. After leaving the reaction mixture aside at room temperature during 70 hours, it is evaporated to dryness and the residue is dissolved in ether. The organic phase is washed with a 5% sodium bicarbonate solution and with water, dried over anhydrous sodium sulfate and concentrated in vacuo. The resulting 1-benzoyl-4-ethoxycarbonylmethylthio-3-methoxycarbonyl-1,2,5,6-tetrahydro-pyridine is obtained as an oil (Yield: 100%) and used directly in the next step:

Provenance & Evidence