Acetic Anhydride → HCID 12414551, compound

Participants

Reaction Steps

A solution of 5-o-chlorobenzyl-2-ethoxycarbonyl-3-hydroxy-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine (35.3 g; 0.1 mole) in acetic anhydride (200 cc) is refluxed during one hour, under a nitrogen atmosphere. The reaction mixture is then evaporated to dryness and the residue is dissolved in ether. The organic phase is washed with water, dried over anhydrous sodium sulfate, treated with vegetable charcoal, filtered and evaporated in vacuo. The resulting pale yellow crystals are recrystallized from cyclohexane; M.p. = 110° C; Yield: 31.9 g (80%).

Provenance & Evidence