Pyruvamide → 2-(Phenethylhydrazono)-propionamide

HRID 2163682Notes

Reaction equation

HRID 2163682 reaction equation
Cl.[CH2:2]([NH:10][NH2:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[C:12]([NH2:17])(=[O:16])[C:13]([CH3:15])=O.O.O.O.C([O-])(=O)C.[Na+]>O>[CH2:2]([NH:10][N:11]=[C:13]([CH3:15])[C:12]([NH2:17])=[O:16])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 79088PyruvamideHCID 154983Phenelzine hydrochlorideHCID 23665404Sodium Acetate Trihydrate

Product 1

HCID 731836722-(Phenethylhydrazono)-propionamide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

3.4 g. Phenethylhydrazine hydrochloride are dissolved in 10 ml. water and mixed with 1.7 g. pyruvamide dissolved in 50 ml. water. 2.1 g. sodium acetate trihydrate are added thereto and the reaction mixture well shaken up. 2-(Phenethylhydrazono)-propionamide crystallizes out. It is filtered off and recrystallized from a mixture of cyclohexane and toluene. The yield is 2.0 g. (50% of theory); m.p. 78° C. (decomp.).

Workup

  1. custom2-(Phenethylhydrazono)-propionamide crystallizes out
  2. filtrationIt is filtered off
  3. customrecrystallized from a mixture of cyclohexane and toluene

Sources & evidence

ORD record
ord-49ad3ce14cfc40159a02900a5772a706
Source dataset
uspto-grants-1979_01
Patent number
US04136196

Reaction notes

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