Sodium Hydroxide → 10-Hydroxy-5,5-dimethyl-8-(1,2-dimethylheptyl)-1,2,3,4-tetrahydro-5H-[1]benzopyrano[4,3-c]pyridine-2-acetic acid

HRID 2163808Notes

Reaction equation

HRID 2163808 reaction equation
[OH:1][C:2]1[C:7]2[C:8]3[CH2:9][N:10]([CH2:18][C:19]([O:21]CC)=[O:20])[CH2:11][CH2:12][C:13]=3[C:14]([CH3:17])([CH3:16])[O:15][C:6]=2[CH:5]=[C:4]([CH:24]([CH3:32])[CH:25]([CH3:31])[CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH:3]=1.[OH-].[Na+]>CO>[OH:1][C:2]1[C:7]2[C:8]3[CH2:9][N:10]([CH2:18][C:19]([OH:21])=[O:20])[CH2:11][CH2:12][C:13]=3[C:14]([CH3:17])([CH3:16])[O:15][C:6]=2[CH:5]=[C:4]([CH:24]([CH3:32])[CH:25]([CH3:31])[CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 21321136Ethyl 10-hydroxy-5,5-dimethyl-8-(1,2-dimethylheptyl)-1,2,3,4-tetrahydro-5H-[1]benzopyrano[4,3-c]pyridine-2-acetate

Product 1

HCID 2132114310-Hydroxy-5,5-dimethyl-8-(1,2-dimethylheptyl)-1,2,3,4-tetrahydro-5H-[1]benzopyrano[4,3-c]pyridine-2-acetic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The above-titled compound was obtained by hydrolyzing the product of Example 9 with dilute aqueous sodium hydroxide in methanol; m.p. 192-195°; after recrystallization from ethanol.

Workup

  1. customafter recrystallization from ethanol

Sources & evidence

ORD record
ord-d551e9c08e52484abcd9ae270260f874
Source dataset
uspto-grants-1979_01
Patent number
US04137232

Reaction notes

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