反应详情

Pd (10 wt % on activated carbon) (10 mg, cat.) was added to a degassed solution of 2-(4-{1-azido-2-[4-(2,2-dimethylbutyl)-1-trityl-1H-imidazol-2-yl]ethyl}phenyl)-5-fluoropyridine (110 mg, 0.17 mmol) in methanol (6 mL). After stirring under an atmosphere of hydrogen overnight, the reaction mixture was filtered through celite rinsing with methanol. The filtrate was concentrated to afford 2-[4-(2,2-dimethylbutyl)-1-trityl-1H-imidazol-2-yl]-1-[4-(5-fluoropyridin-2-yl)phenyl]ethanamine which was used in the next step without further purification.

1. filtrationthe reaction mixture was filtered
2. washthrough celite rinsing with methanol
3. concentrationThe filtrate was concentrated