反应详情

A mixture of 7.2 g (0.022 moles) of 8-chloro-1-methyl-6-phenyl-3,3a,4,6-tetrahydro-5H-imidazo[1,5-a][1,5]benzodiazepin-5-one, 45 g of activated manganese dioxide and 1.5 l. of toluene was stirred and refluxed for 45 minutes. The manganese dioxide was filtered off and washed well with tetrahydrofuran and methylene chloride. The filtrate was evaporated and the residue was crystallized from ethyl acetate to yield end product with mp 276°-278° C.

1. temperaturerefluxed for 45 minutes
2. filtrationThe manganese dioxide was filtered off
3. washwashed well with tetrahydrofuran and methylene chloride
4. customThe filtrate was evaporated
5. customthe residue was crystallized from ethyl acetate
6. customto yield end product with mp 276°-278° C.