Ethanol → HCID 86736268, compound

Participants

Reaction Conditions

Reaction Steps

750 g (6 mols + 25%) of phosgene and 2 liters of dry, ethanol-free methylene chloride were placed in a 10 liter reactor, cooled to -30° C. A solution of 6 mols (780 g) of hydroxyethyl methacrylate and 6 mols (480 g) of pyridine in 1 liter of methylene chloride was added to this mixture over a period of 1 hour 30 minutes, the temperature being kept at between -10° and -15° C. After two hours of stirring at -10° C., the excess phosgene was removed by degassing with nitrogen. After removing the pyridine hydrochloride by filtration, the solution was rapidly washed with 2 liters of ice-cold water. The organic phase was decanted, dried over magnesium sulphate and concentrated under reduced pressure; 1,040 g of ethyl methacrylate chloroformate were thus obtained in a yield of 90%.

Provenance & Evidence